ubiquitin-conjugating enzyme E2 Z (ubiquitin-protein ligase Z, ubiquitin carrier protein Z, UBE2Z)

Function

• ubiquitin conjugation, 2nd step
• catalyzes the covalent attachment of ubiquitin to other proteins

ATP + ubiquitin + protein lysine
              <-->
AMP + diphosphate + protein N-ubiquityllysine

Structure

belongs to the ubiquitin-conjugating enzyme family

Compartment

cytoplasm, nucleus

Alternative splicing

named isoforms=2

Expression

• widely expressed
• highly expressed in placenta, pancreas, spleen & testis

More general terms

• ubiquitin-conjugating protein E2 (ubiquitin carrier protein)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9H832.html