plasma retinol binding protein; PRBP; retinol binding protein 4 (RBP4, PRO2222)
Jump to navigation
Jump to search
Function
- transports retinol from the liver to peripheral tissues
- in plasma, the RBP-retinol complex interacts with transthyretin, which prevents its loss by renal glomerular filtration
Structure
- belongs to the calycin superfamily, lipocalin family
Compartment
Pathology
- defects are a cause of retinol-binding protein deficiency
- RBP4 levels correlate with insulin resistance[2]; RBP4 may play role in insulin resistance[2]
More general terms
Additional terms
References
- ↑ Tietz Fundamentals of Clinical Chemistry 3rd ed, WB Saunders, 1987 pg 334
- ↑ 2.0 2.1 2.2 Graham TE et al, Retinol-binding protein 4 and insulin resistance in lean, obese and diabetic subjects. N Engl J Med 2006; 354:2552 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16775236
- ↑ UniProt http://www.uniprot.org/uniprot/P02753.html
- ↑ Mutations of the RBP4 gene; Retina International's Scientific Newsletter http://www.retina-international.com/sci-news/rlbp4mut.htm
- ↑ Wikipedia; Retinol-binding protein 4 http://en.wikipedia.org/wiki/retinol_binding_protein_4