fatty acid-binding protein-5, psoriasis-associated fatty acid-binding protein homolog

Function

• lipid transport protein
• high specificity for fatty acids (stearate)
• highest affinity for C18 chain length
• decreasing chain length or introducing double bonds reduces the affinity
• may be involved in keratinocyte differentiation

Structure

• forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior
• belongs to the calycin superfamily, fatty-acid binding protein (FABP) family

Compartment

cytoplasm

Expression

• keratinocytes

Pathology

highly expressed in psoriatic skin

More general terms

• fatty acid/retinol binding protein family

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2171
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=728641
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2171
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:728641
• OMIM: https://mirror.omim.org/entry/605168
• UniProt: http://www.uniprot.org/uniprot/Q01469.html