rhomboid-related protein 3 (ventrhoid transmembrane protein, RHBDL3, RHBDL4, VRHO)

Function

• role in regulated intramembrane proteolysis & subsequent release of functional polypeptides from their membrane anchors (putative)
• cleaves type-1 transmembrane domains using a catalytic triad composed of serine, histidine & asparagine (charge-relay) contributed by different transmembrane domains

Structure

• belongs to the peptidase S54 family
• contains 2 EF-hand domains

Compartment

membrane

More general terms

• rhomboid-related protein
• Ca+2 binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/P58872.html