solute carrier family 25 member 13; Ca+2-binding mitochondrial carrier protein Aralar2; citrin; mitochondrial aspartate glutamate carrier 2 (SLC25A13, ARALAR2)

Function

• Ca+2-dependent mitochondrial aspartate & glutamate carrier
• may have a function in the urea cycle
• binds Ca+2

Structure

• belongs to the mitochondrial carrier family
• contains 4 EF-hand domains
• contains 3 solcar repeats

Compartment

• mitochondrial inner membrane

Expression

• high levels in liver & low levels in kidney, pancreas, placenta, heart & brain

Pathology

• defects in SLC25A13 are the cause of:
  • citrullinemia type 2
  • neonatal intrahepatic cholestasis due to citrin deficiency (NICCD)

More general terms

• transmembrane 6 protein
• Ca+2 binding protein
• mitochondrial membrane protein
• solute carrier family 25 (SLC25, SLC25A)

Additional terms

• citrullinemia type 2

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10165
• OMIM: https://mirror.omim.org/entry/603471
• OMIM: https://mirror.omim.org/entry/603859
• OMIM: https://mirror.omim.org/entry/605814
• UniProt: http://www.uniprot.org/uniprot/Q9UJS0.html