calumenin; crocalbin; IEF SSP 9302 (CALU)

Function

• role in regulation of vitamin K-dependent carboxylation of multiple amino-terminal glutamate residues
• seems to inhibit gamma-carboxylase GGCX
• binds 7 Ca+2 with a low affinity (putative)
• interacts with GGCX (putative)

Structure

• belongs to the CREC family
• contains 6 EF-hand domains

Compartment

• endoplasmic reticulum lumen
• secreted
• melanosome: stages 1-4
• sarcoplasmic reticulum lumen (putative)

Alternative splicing

named isoforms=2

Expression

• ubiquitously expressed
• expressed at high levels in heart, placenta & skeletal muscle
• expressed at lower levels in lung, kidney & pancreas
• expressed at very low levels in brain & liver

More general terms

• Ca+2 binding protein
• glycoprotein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=813
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:813
• OMIM: https://mirror.omim.org/entry/603420
• UniProt: http://www.uniprot.org/uniprot/O43852.html