tescalcin; TSC; calcineurin B homologous protein 3; CHP3 (TESC)

Function

• essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation
• interacts with SLC9A1/NHE1

Cofactor: binds Ca+2

Structure

contains 1 EF-hand domain

Compartment

• cytoplasm (putative)
• colocalizes with SLC9A1 at the cell membrane

Alternative splicing

named isoforms=2

Expression

• abundantly expressed in heart
• also expressed at a lower level in adult testis & salivary gland, & in the placenta
• strongly up-regulated in K562 cells treated by PMA to promote megakaryocytic differentiation, but not when treated by DMSO to promote granulocytic differentiation or by hemin to promote erythroid differentiation (at protein level)

More general terms

• myristoylated protein
• Ca+2 binding protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54997
• OMIM: https://mirror.omim.org/entry/611585
• UniProt: http://www.uniprot.org/uniprot/Q96BS2.html