Grancalcin (GCA GCL)

Function

• may play a role in granule-membrane fusion & degranulation
• binds Ca+2 with high affinity

Structure

• homodimer
• contains 4 EF-hand domains

Compartment

• cytoplasm, membrane
• 50% cytoplasmic, 50% membrane associated
• attached to membranes & granules

More general terms

• Ca+2 binding protein
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/P28676.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=25801
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:25801
• OMIM: https://mirror.omim.org/entry/607030