ribophorin-2; dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 2; dolichyl-diphosphooligosaccharide-protein glycosyltransferase 63 kD subunit; RIBIIR; RPN-II (RPN2)

Function

• essential subunit of N-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to Asn within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains
• component of the oligosaccharyltransferase (OST) complex

Structure

belongs to the SWP1 family

Compartment

• endoplasmic reticulum membrane
• multi-pass membrane protein (putative)

Alternative splicing

named isoforms=2

Expression

expressed in all tissues tested

More general terms

• transmembrane 3 protein
• ribophorin (Sec61p)
• glycoprotein
• phosphoprotein

Component of

• N-oligosaccharyl transferase (OST)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6185
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6185
• OMIM: https://mirror.omim.org/entry/180490
• UniProt: http://www.uniprot.org/uniprot/P04844.html