ribophorin-1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kD subunit; ribophorin I; RPN-I (RPN1)

Function

• essential subunit of N-oligosaccharyl transferase enzyme which catalyzes transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to Asn within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains
• component of the oligosaccharyltransferase (OST) complex

Structure

belongs to the OST1 family

Compartment

• endoplasmic reticulum membrane
• single-pass type 1 membrane protein. melanosome

Expression

expressed in all tissues tested

More general terms

• ribophorin (Sec61p)

Component of

• N-oligosaccharyl transferase (OST)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6184
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6184
• OMIM: https://mirror.omim.org/entry/180470
• UniProt: http://www.uniprot.org/uniprot/P04843.html