DNA-directed RNA polymerase 1 subunit RPA43 (twist neighbor protein, TWISTNB)

Function

• component of RNA polymerase 1
• role in recruitment of RNA polymerase 1 to rDNA promoters via association with RRN3/TIF-IA

Structure

• belongs to the eukaryotic RPA43 RNA polymerase subunit family

Compartment

nucleus, nucleolus

Expression

• widely expressed
• expressed in all fetal & adult tissues tested, with highest expression in fetal lung, liver, & kidney, & low expression in all adult tissues

More general terms

• protein subunit
• phosphoprotein

Component of

• RNA polymerase 1

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2218
• OMIM: https://mirror.omim.org/entry/608312
• UniProt: http://www.uniprot.org/uniprot/Q3B726.html