malic enzyme 1 (NADP-ME, NADP-dependent malic enzyme, ME1)

Function

• provides cytoplasmic malate from pyruvate

(S)-malate + NADP+ <--> pyruvate + CO2 + NADPH

Cofactor: divalent metal cations, prefers Mg+2 or Mn+2

Structure

• homotetramer
• belongs to the malic enzymes family

Compartment

cytoplasm

Expression

• expressed in all tissues tested including liver, placenta & white adipose tissue

More general terms

• malic enzyme, malate decarboxylase or malate oxidoreductase
• oligomerizing protein

Database

• OMIM: https://mirror.omim.org/entry/154250
• UniProt: http://www.uniprot.org/uniprot/P48163.html