aldehyde dehydrogenase 3 family, member A1 (aldehyde dehydrogenase 3, acetaldehyde dehydrogenase 3, ALDH3A1, ALDH3)

Function

• preferentially oxidizes aromatic aldehyde substrates
• oxidizes furfuraldehyde, but not acetaldehyde, formaldehyde, or pyruvic aldehyde
• may play a role in the oxidation of toxic aldehydes
• preference for NADP

an aldehyde + NAD+/NADP+ + H2O <--> an acid + NADH/NADPH

Kinetic parameters:

• high Km for acetaldehyde

Structure

• homodimer
• belongs to the aldehyde dehydrogenase family

Compartment

cytoplasm

Expression

• high levels in stomach, esophagus & lung
• low level in the liver & kidney

More general terms

• aldehyde dehydrogenase
• oligomerizing protein

Database

• UniProt: http://www.uniprot.org/uniprot/P30838.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:218
• OMIM: https://mirror.omim.org/entry/100660
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=218