sterol-sensing domain

From Aaushi
Jump to navigation Jump to search

Introduction

A multiple transmembrane domain (5 in the case of SCAP) binding site for sterols found in sterol responsive proteins.

More general terms

References

  1. Janowskii et al, The hypocholesterolemic agent LY295427 reverses suppression of sterol regulatory element-binding protein processing mediated by oxysterols. J Biol Chem 276:45408, 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11577112
  2. Osborne T. CREating a SACP-less liver keeps SREBPs pinned in the ER membrane and prevents increased lipid synthesis in response to low cholesterol and high insulin. Genes & Develop 15:1873, 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11485982