sterol-sensing domain
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Introduction
A multiple transmembrane domain (5 in the case of SCAP) binding site for sterols found in sterol responsive proteins.
More general terms
References
- ↑ Janowskii et al, The hypocholesterolemic agent LY295427 reverses suppression of sterol regulatory element-binding protein processing mediated by oxysterols. J Biol Chem 276:45408, 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11577112
- ↑ Osborne T. CREating a SACP-less liver keeps SREBPs pinned in the ER membrane and prevents increased lipid synthesis in response to low cholesterol and high insulin. Genes & Develop 15:1873, 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11485982