K+ voltage-gated channel subfamily G member 1; voltage-gated K+ channel subunit Kv6.1; kH2 (KCNG1)

Function

• probable K+ channel subunit
• may need to associate with another protein to form a functional channel
• may modulate channel activity
• heterotetramer of K+ channel proteins

Structure

• the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
• belongs to the K+ channel family, G (TC 1.A.1.2) subfamily, Kv6.1/KCNG1 sub-subfamily

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• expressed in brain & placenta
• expressed at much lower levels in kidney & pancreas

More general terms

• K+ channel subfamily G
• transmembrane 6 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3755
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3755
• OMIM: https://mirror.omim.org/entry/603788
• UniProt: http://www.uniprot.org/uniprot/Q9UIX4.html