K+ channel subfamily K member 10; outward rectifying K+ channel protein TREK-2; TREK-2 K+ channel subunit (KCNK10, TREK2)

Function

• outwardly-rectifying K+ channel
• produces rapidly activating & non-inactivating outward rectifier K+ currents
• activated by arachidonic acid & other naturally occurring unsaturated free fatty acids

Structure

• belongs to the two pore domain K+ channel (TC 1.A.1.8) family

Compartment

• membrane (potential)

Alternative splicing

named isoforms=3; A, B, C

Expression

• abundantly expressed in pancreas & kidney
• expressed to a lower level in brain, testis, colon, & small intestine
• isoform B is strongly expressed in kidney (primarily in the proximal tubule) & pancreas
• isoform C is abundantly expressed in brain

More general terms

• K+ channel subfamily K
• glycoprotein
• transmembrane 4 protein

Database

• UniProt: http://www.uniprot.org/uniprot/P57789.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54207
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54207
• OMIM: https://mirror.omim.org/entry/605873