Na+/nucleoside cotransporter 2; Na+/nucleoside cotransporter 2; Na+-coupled nucleoside transporter 2; concentrative nucleoside transporter 2; CNT 2; hCNT2; Na+/purine nucleoside co-transporter; SPNT (SLC28A2, CNT2)

Function

• Na+ dependent & purine-selective transporter
• transport characteristics of nucleoside transport system cif or N1 subtype (N1/cif)
  • selective for purine nucleosides & uridine
• role in specific uptake & salvage of purine nucleosides in kidney & other tissues
• inhibited by formycin B

Structure

belongs to the SLC28A transporter family

Compartment

membrane

Expression

• expressed in heart & skeletal muscle > liver, kidney, intestine, pancreas, placenta & brain
• weak expression in lung

More general terms

• Na+/nucleoside cotransporter or nucleoside transporter
• solute carrier family 28 (SLC28, SLC28A)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9153
• OMIM: https://mirror.omim.org/entry/606208
• UniProt: http://www.uniprot.org/uniprot/O43868.html