WAP four-disulfide core domain protein 2 (major epididymis-specific protein E4, epididymal secretory protein E4, protease inhibitor WAP5, WFDC2 HE4 WAP5)

Function

putatative serine protease inhibitor

Structure

contains 2 WAP domains

Compartment

secreted

Alternative splicing

named isoforms=5

Expression

• expressed in a number of normal tissues, including male reproductive system, regions of respiratory tract & nasopharynx
• initially described as being exclusively transcribed in the epididymis

Pathology

• highly expressed in a number of tumors cells lines, including ovarian, colon, breast, lung & renal cell lines

More general terms

• WAP four-disulfide core domain protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q14508.html