glutathione peroxidase-4 (GSH-Px4, phospholipid hydroperoxide glutathione peroxidase, PHGPX, GPX4)

Function

• may play a role in protecting mammals from toxicity of ingested lipid hydroperoxides
• essential for embryonic development
• protects from radiation & oxidative damage

2 glutathione + a lipid hydroperoxide
              <-->
glutathione disulfide + lipid + 2 H2O

Structure

• belongs to the glutathione peroxidase family

Compartment

• mitochondria, cytoplasm

Alternative initiation

• named isoforms=2

Expression

• present primarily in testis

Pathology

• defects in GPX4 may be a cause of infertility

More general terms

• glutathione peroxidase

Database

• UniProt: http://www.uniprot.org/uniprot/P36969.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2879
• OMIM: https://mirror.omim.org/entry/138322
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2879