glutathione peroxidase 3 (GSHPx-3, GPx-3, plasma glutathione peroxidase, GSHPx-P, extracellular glutathione peroxidase, GPx-P, GPX3, GPXP)

Function

• protects cells & enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides & organic hydroperoxide, by glutathione

2 glutathione + H2O2 <--> glutathione disulfide + 2 H2O

Structure

• homotetramer
• belongs to the glutathione peroxidase family
• N-terminus is blocked

Compartment

secreted

Expression

secreted in plasma

More general terms

• glutathione peroxidase

Database

• UniProt: http://www.uniprot.org/uniprot/P22352.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2878
• OMIM: https://mirror.omim.org/entry/138321
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2878