glutathione peroxidase-2 (glutathione peroxidase related protein-2, GPRP, gastrointestinal glutathione peroxidase, GSH-Px-GI, GPX2)

Function

• may play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides
• tert-butyl hydroperoxide, cumene hydroperoxide & linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors

2 glutathione + H2O2 <--> glutathione disulfide + 2 H2O

Structure

• homotetramer
• belongs to the glutathione peroxidase family

Compartment

cytoplasm

Expression

• mostly in liver & gastrointestinal tract,
• not found in heart or kidney

More general terms

• glutathione peroxidase

Database

• UniProt: http://www.uniprot.org/uniprot/P18283.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2877
• OMIM: https://mirror.omim.org/entry/138319
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2877