peroxisomal acyl-coenzyme A oxidase 2; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase; trihydroxycoprostanoyl-CoA oxidase; THCA-CoA oxidase; THCCox (ACOX2)

Function

• oxidizes CoA esters of bile acid intermediates di- & tri-hydroxycholestanoic acids
• heterodimer (putative)

Cofactor: FAD (putative)

Structure

belongs to the acyl-CoA oxidase family

Compartment

peroxisome

Expression

• present in all tissues tested:
  • heart, brain, placenta, lung, liver, skeletal muscle, kidney & pancreas
  • most abundant in heart, liver & kidney

More general terms

• acyl-coenzyme A oxidase (ACOX)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8309
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8309
• OMIM: https://mirror.omim.org/entry/601641
• UniProt: http://www.uniprot.org/uniprot/Q99424.html