peroxisomal acyl-coenzyme A oxidase 1; AOX; palmitoyl-CoA oxidase; straight-chain acyl-CoA oxidase; SCOX (ACOX1)

Function

• catalyzes desaturation of very long chain acyl-CoAs to 2-trans-enoyl-CoAs
• lipid metabolism; peroxisomal fatty acid beta-oxidation

acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2

Cofactor: FAD

Structure

belongs to the acyl-CoA oxidase family

Compartment

peroxisome

Alternative splicing

named isoforms=2

Pathology

• defects in ACOX1 are the cause of adrenoleukodystrophy pseudoneonatal

More general terms

• acyl-coenzyme A oxidase (ACOX)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51; -.
• OMIM: https://mirror.omim.org/entry/264470
• OMIM: https://mirror.omim.org/entry/609751
• UniProt: http://www.uniprot.org/uniprot/Q15067.html