Selenocysteine lyase (hSCL, SCLY, SCL)

Function

• catalyzes decomposition of L-selenocysteine to L-alanine & elemental selenium (putative)

L-selenocysteine + reduced acceptor
              <-->
selenide + L-alanine + acceptor

Cofactor: pyridoxal phosphate (putative)

Structure

• homodimer (putative)
• belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family

Compartment

cytoplasm (putative)

Alternative splicing

named isoforms=2

Expression

regulated by AP1

Pathology

• up-regulated in acute glomerulonephritis

More general terms

• lyase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5154
• UniProt: http://www.uniprot.org/uniprot/Q96I15.html