Kynurenine--oxoglutarate transaminase 3 (kynurenine aminotransferase 3, KAT3, cysteine-S-conjugate beta-lyase 2, CCBL2, KAT3, RBMXL1)

Function

• catalyzes irreversible transamination of the L-tryptophan metabolite L-kinurenine to form kynurenic acid
• may catalyze the beta-elimination of S-conjugates & Se-conjugates of L-selenocysteine, resulting in the cleavage of the C-S or C-Se bond (putative)

L-kynurenine + 2-oxoglutarate
           <-->
4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate

RS-CH(2)-CH(NH3(+))COO(-) <--> RSH + NH3 + pyruvate

Cofactor: pyridoxal phosphate (putative)

Structure

• homodimer (putative)
• belongs to the class-1 pyridoxal-phosphate-dependent aminotransferase family

Alternative splicing

named isoforms=2

More general terms

• aminotransferase
• lyase

Database

• UniProt: http://www.uniprot.org/uniprot/Q6YP21.html