sphingosine-1-phosphate lyase 1 (SP-lyase, hSPL, sphingosine-1-phosphate aldolase, SGPL1, KIAA1252)

Function

• sphingolipid metabolism
• cleaves phosphorylated sphingoid bases, i.e. sphingosine-1-phosphate, into fatty aldehydes & phosphoethanolamine
• elevates stress-induced ceramide production
• promotes apoptosis

sphinganine-1-phosphate
       <-->
phosphoethanolamine + palmitaldehyde

Cofactor: pyridoxal phosphate

Compartment

endoplasmic reticulum membrane

Expression

expressed in liver, kidney

More general terms

• lyase

Database

• OMIM: https://mirror.omim.org/entry/603729
• UniProt: http://www.uniprot.org/uniprot/O95470.html