spermidine synthase; SPDSY; putrescine aminopropyltransferase (SRM, SPS1, SRML1)

Function

• activity is regulated by availability of decarboxylated S-adenosylmethionine (putative)
• amine & polyamine biosynthesis
• spermidine biosynthesis
• spermidine from putrescine: step 1/1

S-adenosylmethioninamine + putrescine
       <-->  S-methyl-5'-thioadenosine + spermidine

Structure

• homodimer or homotetramer
• the N-terminus is blocked
• belongs to the spermidine/spermine synthase family

More general terms

• aminotransferase
• synthase

Database

• UniProt: http://www.uniprot.org/uniprot/P19623.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6723
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6723
• OMIM: https://mirror.omim.org/entry/182891