sialic acid synthase; N-acetylneuraminate synthase; N-acetylneuraminate-9-phosphate synthase; N-acetylneuraminic acid phosphate synthase; N-acetylneuraminic acid synthase (NANS, SAS)

Function

• produces N-acetylneuraminic acid (Neu5Ac) & 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN)
• can use N-acetylmannosamine 6-phosphate & mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac & KDN

Phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O
                  <-->
phosphate + N-acetylneuraminate

Phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate + H2O
                   <-->
     N-acylneuraminate 9-phosphate + phosphate

Structure

contains 1 AFP-like domain

Expression

ubiquitous

More general terms

• multifunctional enzyme
• transferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54187
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54187
• OMIM: https://mirror.omim.org/entry/605202
• UniProt: http://www.uniprot.org/uniprot/Q9NR45.html