tRNA dimethylallyltransferase, mitochondrial; isopentenyl-diphosphate:tRNA isopentenyltransferase; IPP transferase; IPPT; hGRO1; tRNA isopentenyltransferase; IPTase (TRIT1, IPT, MOD5)

Function

• catalyzes transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic & mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)

dimethylallyl diphosphate + tRNA = diphosphate + tRNA containing 6-dimethylallyladenosine

Structure

• belongs to the IPP transferase family
• contains 1 matrin-type Zn+2 finger

Compartment

• isoforms 1,4: mitochondria (putative)
• isoforms 2,3,5: cytoplasm (putative)

More general terms

• transferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54802
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54802
• UniProt: http://www.uniprot.org/uniprot/Q9H3H1.html