valacyclovir hydrolase; VACVase; biphenyl hydrolase-like protein; biphenyl hydrolase-related protein; Bph-rp; breast epithelial mucin-associated antigen (MCNAA, BPHL)
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Function
- serine hydrolase
- catalyzes hydrolytic activation of amino acid ester prodrugs of nucleoside analogs, including valacyclovir & valganciclovir
- activates valacyclovir to acyclovir
- role in detoxification processes
Structure
- monomer
- belongs to the AB hydrolase superfamily, lipase family
Alternative splicing
named isoforms=2
Expression
- expressed in liver, kidney > heart, intestine, skeletal muscle