trefoil factor 2; spasmolysin; spasmolytic polypeptide; SP (TFF2, SML1)

Function

• inhibits gastrointestinal motility & gastric acid secretion
• could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains

Structure

contains 2 P-type (trefoil) domains

Compartment

secreted

Expression

stomach

More general terms

• cell adhesion protein
• secreted protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7032
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7032
• OMIM: https://mirror.omim.org/entry/182590
• UniProt: http://www.uniprot.org/uniprot/Q03403.html