bone sialoprotein 2; bone sialoprotein II; BSP II; cell-binding sialoprotein; integrin-binding sialoprotein (IBSP, BNSP)

Function

• binds tightly to hydroxyapatite
  • segments of clustered carboxyl groups may mediate the strong binding to hydroxyapatite
• appears to form an integral part of the mineralized matrix
• probably important to cell-matrix interaction
• promotes Arg-Gly-Asp-dependent cell attachment

Structure

• N-glycosylated
  • glycans consist of sialylated & core-fucosylated bi-, tri- & tetra-antennary chains
• O-glycosylated at eight sites
• mucin-type glycans contain gal, GlcNAc, galNAc & terminal neuAc
• sulfated on either Tyr-313 or Tyr-314

Compartment

secreted

More general terms

• sialoglycoprotein
• cell adhesion protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3381
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3381
• OMIM: https://mirror.omim.org/entry/147563
• UniProt: http://www.uniprot.org/uniprot/P21815.html