syncoilin-1; syncoilin intermediate filament 1 (SYNC1, SYNC)

Introduction

interacts with DES & DTNA (putative)

Structure

belongs to the intermediate filament family

Compartment

• cytoplasm, perinuclear region
• in skeletal muscle, colocalizes with DES & DTNA, & is localized at the myotendinous & neuromuscular junctions, sarcolemma & Z-lines
• in myotubes, detected in a punctate cytoplasmic pattern (putative)

Pathology

• up-regulated at the sarcolemma in individuals with various forms of neuromuscular disease

More general terms

• intermediate filament protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9H7C4.html