calponin-2; calponin H2, smooth muscle; neutral calponin (CNN2)

Function

• thin filament-associated protein implicated in regulation & modulation of smooth muscle contraction
• capable of binding to actin, calmodulin, troponin C & tropomyosin
• interaction of calponin with actin inhibits actomyosin Mg-ATPase activity

Structure

• belongs to the calponin family
• contains 3 calponin-like repeats
• contains 1 CH (calponin-homology) domain

Expression

• expressed in heart & smooth muscle

More general terms

• calponin
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q99439.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1265
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1265
• OMIM: https://mirror.omim.org/entry/602373