glycophorin-B; PAS-3; sialoglycoprotein delta; SS-active sialoglycoprotein; CD235b (GYPB, GPB)

Function

• minor sialoglycoprotein in erythrocyte membranes

Structure

• O-glycosylated: the N-terminal extracellular domain is heavily glycosylated on Ser & Thr
• belongs to the glycophorin A family

Compartment

membrane

Polymorphism

• along with GYPA, GYPB is responsible for the MNS blood group
• the molecular basis of the S/s blood group antigen is a single variation in position 48; Thr-48 corresponds to s=MSN4 & Met-48 to S=MNS3

More general terms

• glycophorin

Database

• UniProt: http://www.uniprot.org/uniprot/P06028.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2994
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2994
• OMIM: https://mirror.omim.org/entry/111740