GPI mannosyltransferase 1; GPI-MT-1; phosphatidylinositol-glycan biosynthesis class M protein; PIG-M (PIGM)

Function

• mannosyltransferase
• glycosylphosphatidylinositol-anchor biosynthesis
• transfers 1st alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly
• glycolipid biosynthesis
• glycosylphosphatidylinositol-anchor biosynthesis
• stabilized by PIGX, functions in conjunction with PIGX

Structure

belongs to the PIGM family

Compartment

endoplasmic reticulum membrane

Pathology

• defects in PIGM are the cause of glycosylphosphatidylinositol deficiency

More general terms

• transmembrane 10 protein
• GPI mannosyltransferase

Database

• UniProt: http://www.uniprot.org/uniprot/Q9H3S5.html