complement fixation

Indications

• widely used in laboratories for the detection of antigen or antibodies

Principle

• firmly attaching or fixing complement in serum by antigen- antibody complex so that it is no longer available additional complement-mediated functions
• in complement-fixation tests, the 2nd system generally serves as an indicator of complement fixation in the 1st system, i.e. erythrocytes plus a hemolysin

More general terms

• detection technique