sidekick homolog 1 (SDK1)

Function

• cell adhesion protein
• guides axonal terminals to specific synapses in developing neurons

Structure

• contains 13 fibronectin F3 modules
• contains 6 Ig-like C2-type domains

Compartment

membrane (potential)

Alternative splicing

named isoforms=3

Expression

renal glomeruli

Pathology

• podocyte dysfunction in HIV-associated nephropathy
• up-regulated in glomeruli in HIV-associated nephropathy
• significantly overexpressed is diseased glomeruli

More general terms

• sidekick homolog

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=221935
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:221935
• OMIM: https://mirror.omim.org/entry/607216
• UniProt: http://www.uniprot.org/uniprot/Q7Z5N4.html