peroxisomal membrane protein PEX16; peroxin-16; peroxisomal biogenesis factor 16 (PEX16)

Function

• required for peroxisome membrane biogenesis
• may play a role in early stages of peroxisome assembly
• can recruit other peroxisomal proteins, such as PEX3 & PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER)
• may function as receptor for PEX3 interacts with PEX19

Structure

belongs to the peroxin-16 family

Compartment

• peroxisome membrane; multi-pass membrane protein
• endoplasmic reticulum membrane

Alternative splicing

named isoforms=2

Pathology

• defects in PEX16 are the cause of peroxisome biogenesis disorder complementation group 9
• defects in PEX16 are a cause of Zellweger syndrome (ZWS)

More general terms

• peroxisomal membrane protein (peroxin)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9409
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9409
• OMIM: https://mirror.omim.org/entry/214100
• OMIM: https://mirror.omim.org/entry/601539
• OMIM: https://mirror.omim.org/entry/603360
• UniProt: http://www.uniprot.org/uniprot/Q9Y5Y5.html