prolyl 4-hydroxylase alpha 2; 4-PH alpha-2; procollagen-proline-2-oxoglutarate-4-dioxygenase alpha-2 subunit (P4HA2, P4HA)
Jump to navigation
Jump to search
Function
- catalyzes post-translational formation of 4-hydroxyproline in -Xaa-Pro-gly- sequences in collagens & other proteins
procollagen L-proline + 2-oxoglutarate + O2 <--> procollagen trans-4-hydroxy-L-proline + succinate + CO2
Structure
- heterotetramer of two alpha-2 chains & two beta chains (the beta chain is the multi-functional PDI)
- belongs to the P4HA family
- contains 1 PKHD (prolyl/lysyl hydroxylase) domain
- contains 1 TPR repeat
Compartment
Alternative splicing
named isoforms=2