UDP-glucuronosyltransferase 1-9; UDPGT 1-9; UGT1*9; UGT1-09; UGT1.9; UDP-glucuronosyltransferase 1-I; UGT-1I; UGT1I; UDP-glucuronosyltransferase 1A9; lugP4 (UGT1A9, GNT1, UGT1)
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Function
- role in conjugation & subsequent elimination of potentially toxic xenobiotics & endogenous compounds
- specificity for phenols
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside
Structure
belongs to the UDP-glycosyltransferase family
Compartment
- microsome
- endoplasmic reticulum membrane
Alternative splicing
- named isoforms=1
- a number of isoforms may be produced
- isoforms have a different N-terminal domain & a common C-terminal domain of 245 residues
Expression
liver