UDP-glucuronosyltransferase 1-8; UDPGT 1-8; UGT1*8; UGT1-08; UGT1.8; UDP-glucuronosyltransferase 1-H; UGT-1H; UGT1H; UDP-glucuronosyltransferase 1A8 (UGT1A8, GNT1, UGT1)

Function

• role in conjugation & subsequent elimination of potentially toxic xenobiotics & endogenous compounds

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

Structure

belongs to the UDP-glycosyltransferase family

Compartment

• microsome
• endoplasmic reticulum membrane

Alternative splicing

• named isoforms=1
• anumber of isoforms may be produced
• isoforms have a different N-terminal domain & a common C-terminal domain of 245 residues

Expression

colon specific

More general terms

• UDP-glucuronosyltransferase-1 (UDPGT-1)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54576
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54576
• OMIM: https://mirror.omim.org/entry/191740
• OMIM: https://mirror.omim.org/entry/606433
• UniProt: http://www.uniprot.org/uniprot/Q9HAW9.html