UDP-glucuronosyltransferase 1-7; UDPGT 1-7; UGT1*7; UGT1-07; UGT1.7; UDP-glucuronosyltransferase 1-G; UGT-1G; UGT1G; UDP-glucuronosyltransferase 1A7 (UGT1A7, GNT1, UGT1)

Function

• role in the conjugation & subsequent elimination of potentially toxic xenobiotics & endogenous compounds

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

Structure

belongs to the UDP-glycosyltransferase family

Compartment

• microsome
• endoplasmic reticulum membrane

Alternative splicing

• named isoforms=1
• a number of isoforms may be produced
• isoforms have a different N-terminal domain & a common C-terminal domain of 245 residues

Expression

• liver & gastric tissue

Polymorphism

• there are four common allelic UGT1A7 variants which exhibit significant differences in catalytic activity towards 3-,7-, & 9-hydroxy-benzo(a)pyrene
• UGT1A7*3 exhibits a 5.8-fold lower relative Vmax compared to UGT1A7*1, whereas UGT1A7*2 * UGT1A7*4 have a 2.6- & 2.8-fold lower relative Vmax than UGT1A7*1, respectively, suggesting that these polymorphisma confer slow glucuronidation phenotype

More general terms

• UDP-glucuronosyltransferase-1 (UDPGT-1)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54577
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54577
• OMIM: https://mirror.omim.org/entry/191740
• OMIM: https://mirror.omim.org/entry/606432
• UniProt: http://www.uniprot.org/uniprot/Q9HAW7.html