UDP-glucuronosyltransferase-1E (UDPGT-1E, UGT1A4)

Function

• UDPGT is of major importance in the conjugation & subsequent elimination of potentially toxic xenobiotics & endogenous compounds
• glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 & IX-alpha-C12 monoconjugates & diconjugate

UDP-glucuronate + acceptor
               <-->
UDP + acceptor beta-D-glucuronoside

Structure

• belongs to the UDP-glycosyltransferase family

Compartment

• microsome, endoplasmic reticulum

Alternative splicing

• named isoforms=1
• a number of isoforms are produced
• different isozymes have a different N-terminal domain & a common C-terminal domain of 245 residues

Expression

• expressed in liver
• not expressed in skin or kidney
• induced by phenobarbital

Pathology

• defects associated with Gilbert syndrome

More general terms

• UDP-glucuronosyltransferase-1 (UDPGT-1)

Database

• UniProt: http://www.uniprot.org/uniprot/P22310.html
• OMIM: https://mirror.omim.org/entry/143500
• OMIM: https://mirror.omim.org/entry/191740
• OMIM: https://mirror.omim.org/entry/218800
• OMIM: https://mirror.omim.org/entry/606429