UDP-glucuronosyltransferase-1D (UDPGT-1D, UGT1A5, bilirubin-specific isozyme 2, HUG-BR2)

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Function

  • UDPGT is of major importance in the conjugation & subsequent elimination of potentially toxic xenobiotics & endogenous compounds
UDP-glucuronate + acceptor
             <-->
UDP + acceptor beta-D-glucuronoside

Structure

belongs to the UDP-glycosyltransferase family

Compartment

microsome, endoplasmic reticulum

Alternative splicing

  • named isoforms=1
  • a number of isoforms may be produced
  • different isoforms have a different N-terminal domain & a common C-terminal domain of 245 residues

More general terms

References

Database