UDP-glucuronosyltransferase-1D (UDPGT-1D, UGT1A5, bilirubin-specific isozyme 2, HUG-BR2)
Jump to navigation
Jump to search
Function
- UDPGT is of major importance in the conjugation & subsequent elimination of potentially toxic xenobiotics & endogenous compounds
UDP-glucuronate + acceptor <--> UDP + acceptor beta-D-glucuronoside
Structure
belongs to the UDP-glycosyltransferase family
Compartment
microsome, endoplasmic reticulum
Alternative splicing
- named isoforms=1
- a number of isoforms may be produced
- different isoforms have a different N-terminal domain & a common C-terminal domain of 245 residues