UDP-glucuronosyltransferase-1D (UDPGT-1D, UGT1A5, bilirubin-specific isozyme 2, HUG-BR2)

Function

• UDPGT is of major importance in the conjugation & subsequent elimination of potentially toxic xenobiotics & endogenous compounds

UDP-glucuronate + acceptor
             <-->
UDP + acceptor beta-D-glucuronoside

Structure

belongs to the UDP-glycosyltransferase family

Compartment

microsome, endoplasmic reticulum

Alternative splicing

• named isoforms=1
• a number of isoforms may be produced
• different isoforms have a different N-terminal domain & a common C-terminal domain of 245 residues

More general terms

• UDP-glucuronosyltransferase-1 (UDPGT-1)

Database

• UniProt: http://www.uniprot.org/uniprot/P35504.html
• OMIM: https://mirror.omim.org/entry/191740
• OMIM: https://mirror.omim.org/entry/606430