Two-pore calcium channel protein 2 (voltage-dependent calcium channel protein TPC2, TPCN2, TPC2)

Function

• one of the major voltage-gated Ca+2 channel (VDCC) across the plasma membrane

Structure

• homodimer
• belongs to the Ca+2 channel alpha-1 subunit family
• each of the 2 internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) & one positively charged transmembrane segment (S4)
• S4 segments probably represent the voltage-sensor & are characterized by a series of positively charged amino acids at every third position

Compartment

membrane

More general terms

• transmembrane 12 protein
• voltage-dependent Ca+2 channel-alpha

Database

• UniProt: http://www.uniprot.org/uniprot/Q8NHX9.html