mitoferrin-2 (mitochondrial iron transporter 2, solute carrier family 25 member 28, mitochondrial RNA splicing protein 3/4 homolog, MRS3/4, hMRS3/4 , SLC25A28, MFRN2, NPD016)

Function

• mitochondrial iron transporter
• mediates iron uptake
• heme biosynthesis
  • iron delivered into mitochondria, presumably as Fe+2
  • delivered to ferrochelatase to catalyze Fe+2 incorporation into protoprophyrin IX to make heme
• Fe-S cluster assembly in non-erythroid cells

Compartment

mitochondrial inner membrane

Alternative splicing

named isoforms=3

Expression

• ubiquitous
• expressed in placenta, lung, kidney, pancreas, liver, brain, skeletal muscle, heart

More general terms

• mitochondrial membrane protein
• transmembrane 6 protein
• solute carrier family 25 (SLC25, SLC25A)

Database

• UniProt: http://www.uniprot.org/uniprot/Q96A46.html