transmembrane GTPase MFN1; mitofusin-1; Fzo homolog (MFN1)

Function

• transmembrane GTPase
• mediates mitochondrial fusion
• fusion of mitochondria
• acts independently of the cytoskeleton
• overexpression induces formation of mitochondrial networks
• forms homomultimers & heteromultimers with MFN2

Compartment

• outer mitochondrial membrane
• isoform 2 is cytoplasmic

Expression

• ubiquitous
• expressed at slightly higher level in kidney, heart

Pathology

• isoform 2 may be overexpressed in some tumors, i.e. lung cancers

More general terms

• transmembrane 2 protein
• mitochondrial membrane protein
• guanosine triphosphatase (GTPase)

Additional terms

• Charcot-Marie-Tooth disease type 2A1 (hereditary motor sensory neuropathy 2A1, CMT2A1)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55669
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55669
• OMIM: https://mirror.omim.org/entry/608506
• UniProt: http://www.uniprot.org/uniprot/Q8IWA4.html