Na+/H+ exchanger NHE6 (solute carrier family 9 isoform 6, SLC9A6)

Function

• electroneutral exchange of protons for Na+ & K+ across the mitochondrial inner membrane
• contributes to organellar volume & Ca+2 homeostasis

Structure

• belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family

Compartment

mitochondrial membrane

Expression

• ubiquitous
• most abundant in mitochondrion-rich tissues such as brain, skeletal muscle & heart

Pathology

• defects in SLC9A6 are the cause of Christianson X-linked mental retardation syndrome

More general terms

• transmembrane 13 protein
• solute carrier family 9 (SLC9, SLC9A)
• mitochondrial membrane protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1047
• OMIM: https://mirror.omim.org/entry/300231
• OMIM: https://mirror.omim.org/entry/300243
• UniProt: http://www.uniprot.org/uniprot/Q92581.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10479