cytochrome b-c1 complex subunit Rieske, mitochondrial; complex III subunit 5; cytochrome b-c1 complex subunit 5; Rieske iron-sulfur protein; RISP; ubiquinol-cytochrome c reductase iron-sulfur subunit; contains: cytochrome b-c1 complex subunit 11; complex III subunit IX; ubiquinol-cytochrome c reductase 8 kD protein (UQCRFS1)

Function

• high potential 2Fe-2S protein
• component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), a component of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis
• transit peptide of the Rieske protein seems to form part of the bc1 complex & is considered to be the subunit 11/IX of that complex (putative)

QH(2) + 2 ferricytochrome c = Q + 2 ferrocytochrome c + 2 H+

Cofactor:

• binds 1 2Fe-2S cluster per subunit (putative)

Structure

contains 1 Rieske domain

Compartment

• mitochondrial inner membrane

More general terms

• iron sulfur protein
• mitochondrial membrane protein

Component of

• ubiquinol cytochrome c reductase; respiratory complex 3

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7386
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7386
• OMIM: https://mirror.omim.org/entry/191327
• UniProt: http://www.uniprot.org/uniprot/P47985.html